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An inhibitor of EGFRL858RT790M (IC50 1.1 nM) selective for EGFRL858RT790M over BTK wild-type EGFR FAK HER2 and HER4 (IC50s 213 226 255 392 and 704 nM respectively) but also inhibits wild-type EGFR containing an exon 19 deletion EGFRT790M containing an exon 19 deletion EGFRL585R EGFRG192A and EGFRL861Q (IC50s 1.3-12 nM) reduces tumor volume in a PDX mouse model of NSCLC at 25 and 50 mg/kg twice per day
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An internal standard for the quantification of psilocybin by GC- or LC-MS provided as a DEA exempt preparation intended for research and forensic applications
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
A thiol-reactive fluorogenic reagent has been used to detect and quantify thiol-containing amino acids protein and tissue thiols and disulfide linkages ex/em 389/513 nm respectively
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
A pyranocoumarin with diverse biological activities inhibits RANKL-induced osteoclastogenesis of primary mouse BMDMs at 10 UM and LPS-induced NO production in RAW 264.7 macrophages at 100 UM inhibits PAF-induced platelet aggregation in isolated rabbit platelet-rich plasma (IC50 50 UM) and contractions of isolated guinea pig ileum induced by histamine or leukotriene D4 (pD2s 4.84 and 4.34 respectively) decreases ovariectomy-induced bone loss in a mouse model of osteoporosis at 10 mg/kg reduces the number of tumors initiated by DMBA and promoted by TPA in a mouse two-stage model of skin carcinogenesis
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More